During the latter part of the sixteenth century. [fact]
"During the latter part of the sixteenth century the Spanish had to put down slave insurrections in Pachuca, Guanajuato, Juaspaltopic, Alvarado, Coatzacoalcos, Misantla, Jalapa, Huatulco, Tlalixcoyan, Zongolicia, Riconada, Huatusco, Orizaba, Rio Blanco, Anton Lizardo, Medellin, and Cuernavaca."
Cedric J. Robinson, Black Marxism_ The Making o…, loc. 1958